Most current HPC systems are heterogenous and use accelerators. oneAPI is a standardized and portable programming model adapted to heterougenuous computing. In this course we will provide an introduction to Intel's oneAPI implementation, which supports two portable methods of heterougenuous computing: Data Parallel C++ (DPC) with SYCL and OpenMP for C, C++, and Fortran. Both are portable on any major current accelerator. The course will give an introduction in these two programming methods, Intel's libraries like oneMKL and tools for performance analysis, profiling, and debugging. Further an introduction to Intel's DPC compatibility Tool to facilitate code migration from CUDA to SYCL and to Intel's MPI implementation support with GPU awereness completes the program. Insights into migrating an application to oneAPI/SYCL will be provided by GROMACS developers.