Are you an R&D driven tech company or start up? 🌟 Join us on June 10th for the webinar Driving National Growth: Harnessing High-Performance Computing for Industrial Innovation.

During this webinar we will highlight the transformative power of High-Performance Computing (HPC). Explore practical use cases and strategies for leveraging supercomputing in R&D-driven tech companies.

📅 Date: June 10, 2024
🕓 Time: 13:00 – 14:00 (Online)

🎙️ We have great speakers lined up for you:

1️⃣ Dr. Marijn Martens, Synaptica
2️⃣ Professor Gábor Závodszky – UvA & Dutch HPC Coalition
3️⃣ Carlos Teijeiro Barjas, EuroCC Netherlands

Marijn Martens will talk about Predicting the functional consequence of ion channel mutations. Understanding the functional consequences of genetic mutations is key for early diagnosis and precision medicine. For only around 2% of potential pathogenic ion channel mutations, the gain or loss of function effects are known and well quantified. Using these known mutations, Synaptica has trained a machine learning model of all missense mutations in many of the disease-related ion channels. HPC now allows the simulation of molecular dynamics and 3D structures of the individual mutated protein sequences, allowing for deep feature extraction.

Using this approach, Synaptica provides predictions on gain or loss of function for ion channel mutations. Synaptica is currently running a clinical proof of concept clinical trial for a familial case of epilepsy. The results are aimed at medical use in clinical trial screening and treatment for channelopathies, such as epilepsy, muscle and heart diseases.

Gábor Závodszky will give insights about big simulations (road to exascale). During his talk he will also give examples of an extreme detailed simulation of a heart disease and a large-scale (330+ CPU core) cellular blood flow simulation. On top of that he will also review the energy consumption of these large simulations. And what can we predict how they will look like in an exascale execution and on new CPU architectures (with contribution from Eviden. To wrap up his talk, he will share how this fits the national landscape and the forming Dutch HPC Coalition.

Carlos Teijeiro Barjas will be your host and HPC Specialist from EuroCC Netherlands.

Gain valuable insights to elevate your organization’s innovation game.

Register now on linkedin